Stability of Drug Delivery PLGA Nanoparticles: Calorimertric Approach

Abstract

The spherical PLGA nanopanicles (NP) calorimetric investigation is presented in this paper. Such nanoparticles is used for biological active substances (drugs) encapsulating inside of them with the purpose of medicine transferring into the cell. It is clear that without determination of particle stability it is impossible their practical usage. From calorimetric study of PLGA nanoparticles with PLA/PGA ratio 70:30 it was determined the entirety conditions of such particles and the temperature interval, where the particle destructions take place. It was unambiguously shown that for noncoated PLGA NP and for chitosancoated PLGA NP the stability temperature are equal to 37°C and less than physiological temperature, which exclude their practical application. Also it was determined that hermiticity destroy temperature depends on heating rate. At the same time it was established that strongly alkaline and acid area (pH2 - pH9) do not destroy noncoated PLGA NP and chitosancoated PLGA NP what gives possibility for their using orally.